Hyaluronidase injection to remove filler❤

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What is hyaluronidase?

Hyaluronidase is a natural substance found in the body, which is collected from either cows or pigs. It is cleaned up to remove animal substances. It may also be produced in a laboratory that recreates it from human albumin sources. This product is routinely used for reversing  hyluronic acid fillers  such as Restylane, Juvederm,  Belotero and not for over-correction  of Radiesse or Silicon implants.

duck lips before and after hyaluronidase
filler removal hyaluronidase before and after

 Hyaluronidase allergic reaction

There is a simple way to know if a patient is allergic to this product,  inject in a small dose under the skin on the arm. If  patient react with an allergic response then it will be clear that he or she are allergic. If he doesn’t react then he are not allergic.  Allergic reaction is more likely, especially if compounded product was use instead of Vitrase .Vitrase is injected into the same area of the tissue as the hyaluronic acid product  was injected previously. It is an enzyme used to break down these products and works fairly quickly. Severe allergic reactions including anaphylaxis have been reported rarely. Allergy to this product should be included in the differential diagnosis when focal erythema and swelling occur after injection.

how long does hyalase take to work?

Hyaluronidase will start to work within 48 hours and have an effect lasting 2 weeks – additional treatments  can be given within 2 weeks of the first treatment for additional dissolution remaining Juvederm or Restylane.

before & after vascular occlusion treated with hyaluronidase
before & after vascular occlusion treated with hyaluronidase

Hyaluronidase side effects

After  injection local irritation, infection, bleeding and bruising  may occur  , however  these side effects are rare and swelling will resolve with time and  edema is not permanent.

hyaluronidase cost

The cost of hyaluronidase will vary depending on the amount used and the areas of treatment.

Swelling after hyalase injection

Swelling after injection to treat excess fillers is normal. This may take several weeks to months to improve, it is a watery liquid and is not as viscous or thick as the gels of Restylane or Juvederm. The swelling from  injection, therefore, is not as much and goes away quickly.


Dissolving lip filler
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Hyaluronidase is routinely used for reversing hyluronic acid fillers such as Restylane, Juvederm, Belotero and not for over-correction
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Niayesh Beauty Clinic
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8 thoughts on “Hyaluronidase injection to remove filler❤”

  1. Hello, I want to get my cheek, undereye filler dissolved. However I am concerned as I don’t
    like swollen and bruised lids. How long does swelling/bruising usually last after dissolving eyelid fillers?thanks

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    • Thank you Mary6600 for your question
      Bruising is an expected side effect after any procedure involving a needle.
      However in my practice I apply cold compress before and after the procedure. I also find that a single dose of Dexamethasone IM injection just before the procedure reduces eyelid edema and swelling.
      Moreover, applying Arnica cream and avoiding NSAIDS analgesics such as Indomethacin and Aspirin before and after treatment reduce swellling and bruising significantly.
      Best of luck

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  2. Hi, I am 37 years old female and I have 3 months hyaluronic acid cheek fillers which I want to get rid of. I am afraid of hyaluronidase When using hyaluronidase to dissolve a lump, does it only dissolve the lump or is there a risk of it dissolving natural body collagen? I would hate to have one side of my cheek deflated and the other side look good

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    • Thank you for your question
      Hyaluronidase tend to shrink and dehydrate the skin just after application. However, after several weeks everything return to normal condition.
      Having said that, high dosage of hyaluronidase may damage normal hyaluronic acid in the body and should be avoided. Hyaluronidase does have a tendency to spread but if an appropriate dose is injected, the effect should be limited to the area without any side effects.
      Best wishes

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  3. hi, I filled my undereye 18 months ago.It swell in the morning Since it’s been over a year, is it possible for filler to remain there for years? Do you think I should dissolve it? Thank you

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    • Thank you for your question

      It is possible for filler to last longer than the time it is “supposed” to. It does stimulate some production of collagen of your own, and it draws water to the area and cause eyelid edema.
      Tear trough corrction is very tricky and challenging ,needs years of experience, knowledge of anatomy and filler rheology.
      I would recommend dissolving it with hyaluronidase as soon as possible.
      Best wishes

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  4. Hello
    I went to a nurse practitioner and she convinced me to try juvaderm for my tear trough. It’s effective, but now my face looks WEIRD! I can’t pinpoint why, but I’m unhappy with my look now. How long does this take to wear off?

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    • Thank you Sol4456 for your question
      Juvederm may be used in the tear trough to help decrease the depth of static lines so they appear less deep. Juvederm is a hyaluronic acid and may be dissolved with Hyaluronidase. It may take up to 2 years to dissolve on its own depending of which filler was used.
      Best wishes

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